| 000 | 04133nam a22005535i 4500 | ||
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| 001 | 978-981-97-0146-9 | ||
| 003 | DE-He213 | ||
| 005 | 20251030112025.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 240502s2024 si | s |||| 0|eng d | ||
| 020 |
_a9789819701469 _9978-981-97-0146-9 |
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| 024 | 7 |
_a10.1007/978-981-97-0146-9 _2doi |
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| 050 | 4 | _aRC270.8 | |
| 072 | 7 |
_aMJCL _2bicssc |
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| 072 | 7 |
_aMED062000 _2bisacsh |
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_aMJCL _2thema |
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| 100 | 1 |
_aArjmand, Farukh. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut _976270 |
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| 245 | 1 | 0 |
_aAdvances and Prospects of 3-d Metal-Based Anticancer Drug Candidates _h[electronic resource] / _cby Farukh Arjmand, Sartaj Tabassum, Huzaifa Yasir Khan. |
| 250 | _a1st ed. 2024. | ||
| 264 | 1 |
_aSingapore : _bSpringer Nature Singapore : _bImprint: Springer, _c2024. |
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| 300 |
_aXII, 284 p. 1 illus. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 505 | 0 | _a1. Introduction -- 2. Classification of Metal-Based Anticancer Chemotherapeutic Agents -- 3. Interaction Studies of Metal-Based Anticancer Drug Entities with Potential Therapeutic Targets -- 4. Biophysical and Spectroscopic Techniques to Validate the Interaction with Therapeutic targets -- 5. DNA Condensation Processes mediated by Metal-based Drug Entities and Morphological Studies -- 6. Molecular Docking and Computational in silico Investigations of Metal-Based Drug Agents -- 7.Biochemical Mechanistic Pathway of Cell Death Induced by Metal-Based Chemotherapeutic Agents -- 8.Combination Drug Strategies for Targeting Specific Biochemical Pathways for Superior Therapeutic Potency -- 9. Advanced Drug Delivery Strategies for Metal-Based Anticancer Drugs -- 10. Endoplasmic Reticulum(ER) Targeted Metal-Based Anticancer Chemotherapeutic Agents -- 11.Progress and Future Projections in Metal-Based Polymeric Anticancer Compounds -- 12. Conclusions. | |
| 520 | _aThis book reviews the potential of metallodrugs against different cancer. It summarizes the classification of metal-based anti-cancer drugs, their plausible biochemical and mechanistic pathways, combining drug strategies for hitting multiple therapeutic targets at the intracellular level, and advanced drug delivery strategies. The book covers the metallodrugs for the efficacious treatment of diverse cancerous strains and recent advances in drug delivery strategies that are used for developing these metal-based therapeutics as potent anticancer agents in vitro and in vivo. The book also covers different biophysical and analytical techniques for studying metal-ligand and metal-macromolecular interactions. The book further presents the recent examples of metallomics studies on the different types of cell death induced by metal-based anticancer drugs, especially on the three major forms of programmed cell death (PCD) in mammalian cells: apoptosis, autophagy, and regulated necrosis, also called necroptosis. Lastly, the book explores the modulation of reactive oxygen species (ROS) by metallodrugs. | ||
| 650 | 0 |
_aCancer _xTreatment. _963722 |
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| 650 | 0 |
_aCancer. _94311 |
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| 650 | 0 |
_aMetabolism. _92468 |
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| 650 | 0 |
_aBiochemistry. _965465 |
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| 650 | 1 | 4 |
_aCancer Therapy. _973414 |
| 650 | 2 | 4 |
_aCancer Metabolism. _976271 |
| 650 | 2 | 4 |
_aBiochemistry. _965465 |
| 700 | 1 |
_aTabassum, Sartaj. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut _976272 |
|
| 700 | 1 |
_aKhan, Huzaifa Yasir. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut _976273 |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer Nature eBook | |
| 776 | 0 | 8 |
_iPrinted edition: _z9789819701452 |
| 776 | 0 | 8 |
_iPrinted edition: _z9789819701476 |
| 776 | 0 | 8 |
_iPrinted edition: _z9789819701483 |
| 856 | 4 | 0 | _uhttps://doi.org/10.1007/978-981-97-0146-9 |
| 912 | _aZDB-2-SBL | ||
| 912 | _aZDB-2-SXB | ||
| 999 |
_c59609 _d59609 |
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