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024 7 _a10.1007/978-981-97-3637-9
_2doi
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072 7 _aMED000000
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_2thema
100 1 _aBennett, Gabriel.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_975288
245 1 0 _aSenotherapy
_h[electronic resource] :
_bA Potential Pharmacological Strategy for Prolonging Human Lifespan and Healthspan /
_cby Gabriel Bennett.
250 _a1st ed. 2024.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2024.
300 _aXVII, 100 p. 16 illus., 11 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Modern Perspectives on Disability Research,
_x3004-9717
505 0 _aChapter 1. Introduction to Senotherapies -- Chapter 2. The Accumulation of Senescent Cells and Disease -- Chapter 3. Current Research about Senotheraputics -- Chapter 4. Final Comments -- Appendices.
520 _aHistorically, ageing has been regarded as a biological process that is unalterable. Although it is not possible to halt or reverse this process, medical scientists are currently attempting to extend lifespan and healthspan by developing treatments that ensure that the hallmarks of ageing do not resemble someone who is elderly. The accumulation of senescent cells is a hallmark of biological ageing. It is speculated that once the volume of senescent cells exceeds a safe therapeutic threshold the possibility of developing age-associated diseases increases. Senotherapeutic medications, otherwise known as senotherapy, aim to keep the volume of senescent cells below this threshold. These medications either eliminate senescent cells (i.e., senolytic medications) or prevent healthy cells from becoming senescent (i.e., senomorphic medications). While preliminary research shows that senotherapy is a promising strategy for increasing both human lifespan and healthspan, there nevertheless remains many unanswered questions. This book summarises our current research about senescent cell accumulation and age-associated diseases, human trials of senotherapeutic medications, and topics about senotherapy that require more research.
650 0 _aMedical sciences.
_965984
650 0 _aPharmacology.
_967844
650 0 _aPublic health.
_961312
650 1 4 _aHealth Sciences.
_965987
650 2 4 _aPharmacology.
_967844
650 2 4 _aPublic Health.
_961312
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789819736362
776 0 8 _iPrinted edition:
_z9789819736386
830 0 _aSpringerBriefs in Modern Perspectives on Disability Research,
_x3004-9717
_975290
856 4 0 _uhttps://doi.org/10.1007/978-981-97-3637-9
912 _aZDB-2-SLS
912 _aZDB-2-SXS
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