000 04179nam a22005415i 4500
001 978-3-031-55163-5
003 DE-He213
005 20251030112637.0
007 cr nn 008mamaa
008 240719s2024 sz | s |||| 0|eng d
020 _a9783031551635
_9978-3-031-55163-5
024 7 _a10.1007/978-3-031-55163-5
_2doi
050 4 _aQP251-285
072 7 _aPSA
_2bicssc
072 7 _aSCI056000
_2bisacsh
072 7 _aPSA
_2thema
245 1 0 _aMolecular Mechanisms Determining Mammalian Oocyte Quality
_h[electronic resource] :
_bOocyte Developmental Competence, Aneuploidy, and Clinical Relevance /
_cedited by Ahmed Z. Balboula.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2024.
300 _aVII, 129 p. 19 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Anatomy, Embryology and Cell Biology,
_x2192-7065 ;
_v238
505 0 _aChapter 1. Predicting Infertility: How Genetic Variants in Oocyte Spindle Genes Affect Egg Quality -- Chapter 2. Regulation of Oocyte mRNA Metabolism: A Key Determinant of Oocyte Developmental Competence -- Chapter 3. Mechanisms of DNA Damage Response in Mammalian Oocytes -- Chapter 4. How do Environmental Toxicants Affect Oocyte Maturation via Oxidative Stress? -- Chapter 5. Molecular Mechanisms Determining Mammalian Oocyte Quality with the Treatment of Cancer Therapy -- Chapter 6. Telomere Elongation during Pre-implantation Embryo Development.
520 _aAs the age of childbearing increases, reduced female gamete (egg) quality has emerged as the primaery cause of infertility in women. This book addresses molecular mechanisms that regulate oocyte quality as well as intrinsic and extrinsic factors that compromise these mechanisms. Eggs are produced through a unique cell division called meiosis. Oocyte meiosis is initiated early in fetal life. Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I. Following meiotic resumption and during oocyte maturation, tight regulation of nuclear and DNA-related mechanisms ensures proper homologous chromosome segregation prior to another arrest at metaphase II. Any errors prior to completion of meiosis I can lead to chromosome segregation errors and aneuploidy, the most common genetic cause of miscarriage and congenital disorders such as Down syndrome. In addition to nuclear maturation, several cytoplasmic processes are orchestrated to support cell division and to generate developmentally competent eggs capable of supporting fertilization and early embryonic development. The interaction between these nuclear and cytoplasmic processes is critical for producing good-quality oocytes. This volume in the Advances in Anatomy, Embryology and Cell Biology book series presents current reviews by leading experts. It offers valuable insights for researchers, physicians and Ph.D. students interested in reproductive biology, particularly oocyte quality and meiosis.
650 0 _aReproduction.
_980864
650 0 _aPhysiology.
_972764
650 0 _aCytology.
_967436
650 0 _aReproductive health.
_958885
650 1 4 _aReproductive Physiology.
_980865
650 2 4 _aCell Biology.
_967440
650 2 4 _aReproductive Medicine.
_969390
700 1 _aBalboula, Ahmed Z.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_980866
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031551628
776 0 8 _iPrinted edition:
_z9783031551642
830 0 _aAdvances in Anatomy, Embryology and Cell Biology,
_x2192-7065 ;
_v238
_980867
856 4 0 _uhttps://doi.org/10.1007/978-3-031-55163-5
912 _aZDB-2-SBL
912 _aZDB-2-SXB
999 _c61729
_d61729