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020 _a9783031612572
_9978-3-031-61257-2
024 7 _a10.1007/978-3-031-61257-2
_2doi
050 4 _aQH506
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aPSD
_2thema
100 1 _aCarlberg, Carsten.
_eauthor.
_0(orcid)0000-0003-2633-0684
_1https://orcid.org/0000-0003-2633-0684
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_981052
245 1 0 _aAging
_h[electronic resource] :
_bHow Science Works /
_cby Carsten Carlberg, Stine M. Ulven, Eunike Velleuer.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aXV, 175 p. 79 illus., 78 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _a1. The human genome, development and evolution -- 2. Gene expression and epigenetics -- 3. Epigenetics and aging -- 4. Molecular and cellular basis of aging -- 5. Nutrition and aging -- 6. Aging and immunity -- 7. Central role of aging during chronic diseases -- 8. Aging and cancer -- 9. Healthy aging.
520 _aAging is a topic that concerns all of us, since none of us can escape it. The molecular and cellular process is built in every of the billions of cells forming our body. Some of these cells, such as immune cells and red blood cells, live only for a few days to weeks and get life-long constantly replaced by cells produced in the bone marrow. In contrast, there are cells, such as neurons and memory lymphocytes, that get as old as we get. The process of aging limits our maximal life span, which is for our humans 120 years. However, only a very few individuals reached this age. How did their life differ from others that died decades earlier? Is it just the absence of life threatening disease paired with a more healthy life style? Or is it build in in our genome or epigenome? In this book we try to give answers to these questions from the perspectives of evolution, our genome, the epigenomes of our different tissues and cell types and the functionality of our cells. We should try to understand ourselves in detail as well as in a global setting. Basic biology explains cellular mechanisms, such as growth, differentiation, and cell death, which make life as a whole possible. Every (human) organism represents a complex interplay between hundreds of different cell types forming distinctive tissues and organs with specialized tasks. These processes need to be highly orchestrated especially during development, maintenance and aging. Studying the cellular and molecular basis of aging is one of the most fascinating areas but also a great challenge. Nevertheless, research made the biggest steps in elucidating biological processes via studying malfunctions of normal mechanisms leading to different diseases, such as progeroid syndrome and cancer. We will start this book with the understanding of the human genome in relation to principles of evolution. Then we will explain the basics of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin. Next, we will shift to cellular mechanisms of aging and discuss then the impact of nutrition and immunity on the aging process. In the following the relation of aging to so-called aging-related common diseases, such as type 2 diabetes, atherosclerosis, cancer and Alzheimer. Do we get these diseases because we are aging or are we aging because we get one of these diseases? The book will end how we can slow down the aging process so that we can age healthy. In short, healthy aging is not an option but is a must. An ancient poem says “Teach us to number our days, that we may get a heart of wisdom.” It is up to each one of us and a daily decision to live a healthy lifestyle and to be aware of the unique gift of live we all have. .
650 0 _aMolecular biology.
650 0 _aEpigenetics.
_977287
650 0 _aNutrition   .
_968694
650 0 _aMolecular Evolution.
_981053
650 0 _aCancer.
_94311
650 0 _aMetabolism.
_92468
650 1 4 _aMolecular Biology.
650 2 4 _aEpigenetics.
_977287
650 2 4 _aNutrition.
_968694
650 2 4 _aMolecular Evolution.
_981053
650 2 4 _aCancer Biology.
_967829
650 2 4 _aMetabolism.
_92468
700 1 _aUlven, Stine M.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_981054
700 1 _aVelleuer, Eunike.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_981055
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031612565
776 0 8 _iPrinted edition:
_z9783031612589
776 0 8 _iPrinted edition:
_z9783031612596
856 4 0 _uhttps://doi.org/10.1007/978-3-031-61257-2
912 _aZDB-2-SBL
912 _aZDB-2-SXB
999 _c61817
_d61817