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020 _a9783031621314
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024 7 _a10.1007/978-3-031-62131-4
_2doi
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072 7 _aPSF
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072 7 _aSCI017000
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245 1 0 _aOxidative Stress in Cardiovascular-Metabolic Diseases
_h[electronic resource] /
_cedited by Ali Hussein Eid, Firas Kobeissy, Ahmed F. El-Yazbi.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aXII, 298 p. 39 illus., 38 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
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490 1 _aOxidative Stress in Applied Basic Research and Clinical Practice,
_x2197-7232
505 0 _aChapter 1 - Interplay between ROS and gender in the pathogenesis of cardiovascular disease -- chapter 2 -ROS, aging and cardiovascular disease -- Chapter 3 - Combat ROS, prevent CVD -- Chapter 4 -Traumatic-brain injury and CVD: ROS is the link? -- Chapter 5 - Adipose tissue inflammation and CVD: oxidative stress as a catalyst -- Chapter 6 - Oxidative stress in diabetes-compounded CVD -- Chapter 7 - ROS in hypertension: a critical update -- Chapter 8 - ROS in atherosclerosis: what we know.-Chapter 9 - ROS as a key mediator of cardiovasculometabolic disease -- Chapter 10 - Antioxidant Therapy in CVD: hope or hype? -- Chapter 11 - Antioxidants as adjuvant therapy: Evidence from clinical trials.
520 _aThe book dissects the role of oxidative stress in the pathogenesis of the leading causes of global morbidity and mortality, i.e.cardiovascular and metabolic diseases. The chapters discuss topics related to the role reactive oxygen species (ROS) play in hypertension, atherosclerosis,diabetes, obesity and related pathologies. The authors also shed light on gender differences in the onset and pathologies of some of these diseases. Moreover, how ROS and aging interplay to precipitate cardiovasculo-metabolic disease is discussed and highlighted. Preventive measures that can abrogate ROS-induced cardiovasclo-metabolic disease are discussed and clarified in the hope of reducing such a debilitating battery of diseases. A section dedicated to antioxidants as potential therapy is also included. Furthermore, given the complexity of the mechanisms implicated in ROS-modulated responses, it remains challenging to assert a conclusive argument and pre-determined regimen for incorporating antioxidants into conventional therapies. Nonetheless, results from some clinical trials appear promising, warranting the addition of a chapter dedicated to such human trials. In all of the chapters, the molecular, cellular, genetic, and pharmacological mechanisms implicated are covered from an applied science perspective. This is an ideal book for basic researchers in the biomedical field, graduate students in biological and biomedical fields, medical students, instructors in medical and graduate schools, and professionals working for pharmaceutical companies.
650 0 _aCytology.
_967436
650 0 _aStress (Physiology).
_970794
650 0 _aCardiovascular system.
_975583
650 0 _aPhysiology.
_972764
650 0 _aMetabolism.
_92468
650 0 _aMolecular biology.
650 1 4 _aCellular Stress.
_982055
650 2 4 _aCell Biology.
_967440
650 2 4 _aCardiovascular Physiology.
_975584
650 2 4 _aMetabolism.
_92468
650 2 4 _aMolecular Biology.
700 1 _aEid, Ali Hussein.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_982056
700 1 _aKobeissy, Firas.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_979559
700 1 _aEl-Yazbi, Ahmed F.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_982057
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031621307
776 0 8 _iPrinted edition:
_z9783031621321
776 0 8 _iPrinted edition:
_z9783031621338
830 0 _aOxidative Stress in Applied Basic Research and Clinical Practice,
_x2197-7232
_982058
856 4 0 _uhttps://doi.org/10.1007/978-3-031-62131-4
912 _aZDB-2-SBL
912 _aZDB-2-SXB
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