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020 _a9783031583803
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024 7 _a10.1007/978-3-031-58380-3
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100 1 _aFabricant, Peter D.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_982598
245 1 0 _aPractical Clinical Research Design and Application
_h[electronic resource] :
_bA Primer for Physicians, Surgeons, and Clinical Healthcare Professionals /
_cby Peter D. Fabricant.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aXV, 118 p. 37 illus., 15 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart I: Foundational Basics -- Descriptive Statistics -- Comparative Statistics: Categorical Data -- Comparative Statistics: Continuous Data -- Statistical Power and Power Calculations -- Characteristics of a Diagnostic Test: Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value -- Statistical Bias -- The Iterative Process of Designing Successful Clinical Research -- Part II: Choosing and Executing an Appropriate Clinical Study Design -- Randomized Controlled Trials -- Case-Control Studies -- Cohort Studies -- Cross-Sectional Studies -- Case Series and Case Reports -- Part III: Specialized Study Designs -- Propensity Score Matched Studies -- Interrater and Intrarater Reliability Studies -- Clinical Outcome Scale Development and Validation.
520 _aEvery practicing physician, surgeon, advanced practice provider, and allied health professional interacts regularly with peer-reviewed literature: either while creating it, or consuming it. Despite the countless hours over many years spent in formal clinical training, many clinicians and clinician-authors lack advanced training or a working nuanced knowledge of research methodology and study design. Institutions have responded to this gap by reinforcing their ranks with statistical and methodological support in the form of data analysts, epidemiologists, and biostatisticians. However, clinicians are often unable to “talk the methodological talk” to guide them. This ultimately results in a stark disconnect between clinically relevant aspects of research and appropriate study design. Existing research methodology texts are largely written by statisticians, epidemiologists, and other academic public health experts. These are not easily digestible by practicing clinicians who need practical knowledge of this content to design their own research or enhance their understanding of the medical literature. Furthermore, these texts are often too detailed or “in the weeds” with regard to mathematics and statistical mechanics. Practical knowledge is not centrally located; rather, it is spread out among multiple books, articles, and other sources. This book is a concise, accessible, and practical guide for clinicians to read and reference when designing and reviewing clinical research. It is designed to be a standalone text, written “by a clinician, for clinicians” by a practicing clinical research expert who has had advanced formal training in research methodology, biostatistics, and epidemiology. Topics covered include descriptive and comparative statistics, power and sample size calculations, diagnostic tests, bias, and study design. In each chapter, consideration is given to study mechanics, advantages and disadvantages of each design, and illustrative analytical reviews of existing literature.
650 0 _aMedicine.
_963923
650 0 _aClinical medicine
_xResearch.
_974123
650 1 4 _aClinical Medicine.
650 2 4 _aClinical Research.
_974124
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031583797
776 0 8 _iPrinted edition:
_z9783031583810
776 0 8 _iPrinted edition:
_z9783031583827
856 4 0 _uhttps://doi.org/10.1007/978-3-031-58380-3
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912 _aZDB-2-SXM
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