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020 _a9783031664212
_9978-3-031-66421-2
024 7 _a10.1007/978-3-031-66421-2
_2doi
050 4 _aQH671
072 7 _aPSF
_2bicssc
072 7 _aSCI017000
_2bisacsh
072 7 _aPSF
_2thema
245 1 0 _aRole of Autophagy and Reactive Oxygen Species in Cancer Treatment
_h[electronic resource] :
_bPrinciples and Current Strategies /
_cedited by Neeraj Mishra, Ravinder Kumar Kaundal.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Humana,
_c2024.
300 _aVIII, 372 p. 54 illus., 53 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Drug Discovery and Development,
_x2196-9914
505 0 _aPreface -- Autophagy and Reactive Oxygen Species in Cancer: An Introduction -- Reactive Oxygen Species (ROS) and Cancer -- Unveiling Therapeutic Targets: Targeting Mitochondrial ROS for Anticancer Therapy -- Molecular Mechanisms of Autophagy Regulation in Cancer -- Autophagy and multi-drug resistance in cancer -- Interplay between Autophagy and Reactive Oxygen Species (ROS) -- Autophagy, Reactive Oxygen Species and Tumorigenesis -- Role of Autophagy and Oxidative Stress in Cancer Metastasis -- Autophagy-targeted Nanoparticles for the Treatment of Cancer -- Autophagy: A Critical Link between Immune Response and Cancer Progression -- Interplay between Autophagy and Apoptosis in Cancer: Mechanisms and Therapeutic Implications -- Unraveling the Nexus: Mitochondrial Oxidative Stress, Tumour Microenvironment, and Escape from Immune Surveillance -- Current Strategies for Targeting Autophagy and ROS for Cancer Treatment -- Exploring the Potential of Dietary Phytochemicals in Cancer Therapeutics: Modulating Apoptosis and Autophagy -- Clinical Trials and Future Prospects of Autophagy and ROS in Cancer -- Index.
520 _aAutophagy is a catabolic process that eliminates damaged and faulty cellular components via lysosomes. It responds to adverse circumstances like nutritional deficiency, hypoxia, and oxidative damage. Reactive oxygen species (ROS) cause oxidative stress, which is a multidimensional chemical that drives various pathophysiological diseases, including cancer. In addition, the autophagy process has a double role, first preventing tumour formation, but later fostering tumour progression. A growing body of research suggests that autophagy and ROS have a complex interplay in which they can either prevent cancer growth or enhance disease genesis. While a combination of autophagy inhibitor and cytotoxic medicines is now being used in cancer treatment, investigating the potential of autophagy inhibitors for overcoming resistance to different anticancer medications and how this relates to the control of cancer micro environmental stressors raises several questions. Autophagy's dual functions as a safeguarding and cytotoxic process have drawn attention to its significance in the development of cancer.
650 0 _aCell death.
_983443
650 0 _aCancer
_xTreatment.
_963722
650 0 _aPharmacology.
_967844
650 1 4 _aCell Death.
_983444
650 2 4 _aCancer Therapy.
_973414
650 2 4 _aPharmacology.
_967844
700 1 _aMishra, Neeraj.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_974463
700 1 _aKaundal, Ravinder Kumar.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_983445
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031664205
776 0 8 _iPrinted edition:
_z9783031664229
776 0 8 _iPrinted edition:
_z9783031664236
830 0 _aCancer Drug Discovery and Development,
_x2196-9914
_983446
856 4 0 _uhttps://doi.org/10.1007/978-3-031-66421-2
912 _aZDB-2-SBL
912 _aZDB-2-SXB
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