000 04521nam a22006135i 4500
001 978-3-031-64995-0
003 DE-He213
005 20251030112934.0
007 cr nn 008mamaa
008 240903s2024 sz | s |||| 0|eng d
020 _a9783031649950
_9978-3-031-64995-0
024 7 _a10.1007/978-3-031-64995-0
_2doi
050 4 _aQP86
072 7 _aPSA
_2bicssc
072 7 _aSCI072000
_2bisacsh
072 7 _aPSA
_2thema
100 1 _aMuradian, Khachik K.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_983608
245 1 0 _aRejuvenation and Longevity
_h[electronic resource] :
_bIntroduction to Rejuvenology /
_cby Khachik K. Muradian, Vadim E. Fraifeld.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aX, 128 p. 10 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHealthy Ageing and Longevity,
_x2199-9015 ;
_v20
505 0 _aIntroduction to optimistic gerontology -- The origin of life, immortality, and aging -- Cellular learning, decision-making, and rejuvenation -- Sporulation, meiosis and rejuvenation -- Longevity secrets of the three marine beauties—sponges, corals and sea anemones -- Metazoans who live longer than Jeanne Calment -- Transposable elements and rejuvenation of genome -- Embryonic stem cells and the ‘last-minute’ correction -- Muse cells and VSEL stem cells in longevity and rejuvenation -- The paradox of the adult stem cells: Relevance to aging and rejuvenation -- Biological age can be moved in both directions -- Rejuvenation is on its way.
520 _aThis book is a systematic collection and critical analysis of current information on rejuvenation, starting from the evolutionary aspects of the origin of life, immortality, and aging. Models, mechanisms, and types of rejuvenation are the key subjects of the book. Processes like cellular reprogramming, resetting of the aging clock, immortal unicellulars and cell cultures are explored through the lens of rejuvenation. Recent discoveries in this field offer a nuanced view of rejuvenation that has fascinated mankind since early history. There is evidence, though still controversial, indicating that biological time could be reversible. Indeed, under specific experimental conditions, cells can be moved back and forth along the age axis. Differentiation status and replicative age of cells can be modified not only by defined transcription factors, but also by ‘cocktails’ of small molecules originating from natural substances or well-known longevity-promoting drugs. Still in its infancy, such findings open up the perspective of in vivo rejuvenation trials. Special attention is given to the quasi-immortal and extremely long-lived multicellular animal species as well as to the role of rejuvenation in treatment of pathology and healthy aging. Rejuvenation is experiencing a significant growth in recent years. There is ample debate in the scientific and near-scientific community about the ethics of rejuvenation and radical life span extension. This book aims to take a balanced and scientific approach to the mirage of immortality and ever-lasting youth and serves as a valuable resource for parties on both sides of the coin.
650 0 _aAging.
_962945
650 0 _aStem cells.
_967435
650 0 _aGeriatrics.
_964200
650 0 _aCytology.
_967436
650 0 _aMedicine
_xResearch.
_962598
650 0 _aBiology
_xResearch.
_965629
650 1 4 _aAgeing.
_978416
650 2 4 _aStem Cell Biology.
_967439
650 2 4 _aGeriatrics.
_964200
650 2 4 _aCellular Senescence.
_983609
650 2 4 _aBiomedical Research.
_965633
700 1 _aFraifeld, Vadim E.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_983610
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031649943
776 0 8 _iPrinted edition:
_z9783031649967
776 0 8 _iPrinted edition:
_z9783031649974
830 0 _aHealthy Ageing and Longevity,
_x2199-9015 ;
_v20
_983611
856 4 0 _uhttps://doi.org/10.1007/978-3-031-64995-0
912 _aZDB-2-SBL
912 _aZDB-2-SXB
999 _c63062
_d63062