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020 _a9783031667763
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024 7 _a10.1007/978-3-031-66776-3
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
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072 7 _aMKG
_2thema
245 1 0 _aAdrenoceptors
_h[electronic resource] /
_cedited by Jillian G. Baker, Martin C. Michel, Roger J. Summers.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2024.
300 _aX, 688 p. 70 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHandbook of Experimental Pharmacology,
_x1865-0325 ;
_v285
505 0 _aIntroduction: a short history of adrenoceptor research -- Structures of Adrenoceptors -- Genetic Variants of Adrenoceptors -- Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays -- Signalling of adrenoceptors: canonical pathways and new paradigms -- Presynaptic Adrenoceptors -- Roles of b-adrenoceptor subtypes and therapeutics in human cardiovascular disease:- heart failure, tachyarrhythmias and other cardiovascular disorders -- Adrenoceptors and Hypertension -- Adrenoceptors in the Lower Urinary Tract -- Asthma and COPD: A Focus on b-Agonists – Past, Present and Future -- Adrenoceptors in the Eye- Physiological and Pathophysiological Relevance -- Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments -- Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease -- Clinical use of adrenergic receptor ligands in acute care settings -- Adrenoceptor expression and function in the endocrine pancreas -- b-adrenoceptors in cancer: old players and new perspectives.
520 _aAdrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein-coupled receptors as recognized by a Nobel Prize to Brian Kobilka and Robert J. Lefkowitz. Drugs directly or indirectly targeting adrenoceptors have become guideline-recommended treatments for more than 30 human and various animal diseases. This volume assembles leading experts on various types of adrenoceptor research to provide concise insight into the current standing and future direction of uses of adrenoceptor-targeted drugs and research in this field.
650 0 _aPharmacology.
_967844
650 0 _aDrugs
_xDesign.
_964861
650 1 4 _aPharmacology.
_967844
650 2 4 _aStructure-Based Drug Design.
_971118
700 1 _aBaker, Jillian G.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_983725
700 1 _aMichel, Martin C.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
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700 1 _aSummers, Roger J.
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710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
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776 0 8 _iPrinted edition:
_z9783031667770
776 0 8 _iPrinted edition:
_z9783031667787
830 0 _aHandbook of Experimental Pharmacology,
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_969242
856 4 0 _uhttps://doi.org/10.1007/978-3-031-66776-3
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