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020 _a9783031636813
_9978-3-031-63681-3
024 7 _a10.1007/978-3-031-63681-3
_2doi
050 4 _aQK
072 7 _aPST
_2bicssc
072 7 _aSCI011000
_2bisacsh
072 7 _aPST
_2thema
100 1 _aRoss, Ivan A.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_986255
245 1 0 _aPlant-Based Therapeutics, Volume 2
_h[electronic resource] :
_bThe Brassicaceae Family /
_cby Ivan A. Ross.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aXXIII, 820 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aCh01: The History of Brassicaceae Plants -- Ch-02: The Bioactive Components of Brassicaceae -- Ch-03: Chemical Constituents of Brassicaceae -- Ch-04: Nutrigenomics and Metabolomics of the Bioactive Compounds -- ch-05: The Anticarcinogenic Properties of Brassica Vegetables -- ch-06: Neurodegenerative Diseases -- ch-07: Epigenetic Modulation by Isothiocyanates -- ch-08: Breast Cancer -- ch-09: Brain Cancer -- ch-10: Cancer of the Gastrointestinal Tract -- ch-11: Cancer of the Urinary Bladder -- ch-12: Prostate Cancer -- Ch13: Brassica Vegetables and Hypothyroidism -- ch14: Brassicaceae and Viral Diseases -- ch15:Melatonin in Plants and Animals.
520 _aFor centuries, research has been conducted on the therapeutics of Brassicaceae plants and their health-promoting effects. Cato the Elder (234-149 BCE) documented their properties in his work De agri cultura and recommended using cabbage to compress wounds, swelling, burns, and bone dislocations. For arthritis, he recommended chopped raw cabbage mixed with coriander and cured cabbage mixed with vinegar and honey. In a groundbreaking discovery in the 1990s, scientists at Johns Hopkins University isolated sulforaphane from broccoli, revealing its potent anticancer properties. This naturally occurring compound has proven highly effective, safe, and tolerable and holds immense promise as a chemoprevention agent. It has the potential to combat various cancers, including breast, prostate, gastrointestinal, melanoma, lung, brain, and bladder. But its potential does not stop there. It also shows promise in treating cardiovascular and neurodegenerative diseases and diabetes, offering hope for those affected. The cancer-protecting properties of Brassica plants are mediated through compounds that induce a variety of physiological processes, including antioxidant action, detoxifying enzymes, inducing apoptosis, and cell cycle regulation. Glucosinolate breakdown products can affect several stages of cancer development, including the inhibition of activation enzymes (phase I) and the induction of detoxification enzymes (phase II). Isothiocyanates and indole products formed from glucosinolates regulate cancer cell development by regulating target enzymes, controlling apoptosis, inhibiting angiogenesis, metastasis, and the migration of cancer cells, and blocking the cell cycle. Sulforaphane, found in abundance in broccoli sprouts, plays a crucial role in upregulating the transcriptional activity of specific genes and restoring epigenetic alterations. This is particularly significant as it modifies epigenetic pathways by targeting histone deacetylases and DNA methyltransferases. These modifications, in turn, alter gene transcription and expression, particularly in the case of cancers. This intricate process of gene regulation is a fascinating study area, making broccoli sprouts a compelling component of the 'epigenetic diet.' Sulforaphane induces the cytoprotective enzyme NQO1. The inducible expression of NQO1 is regulated principally through the Keap1-Nrf2-ARE signaling pathway. The activation of the Nrf2-Keap1 signaling pathway heralds the beneficial actions of drugs known to affect Nrf2 signaling, such as dimethyl fumarate, an FDA-approved treatment for multiple sclerosis, and bardoxolone methyl for chronic kidney disease. There is optimism that the overall strategies are moving forward. Sulforaphane-rich broccoli sprout extracts provide one avenue toward this end.
650 0 _aBotany.
_968084
650 0 _aAlternative medicine.
_970733
650 0 _aPharmacology.
_967844
650 0 _aMedicinal chemistry.
650 0 _aAgriculture.
_968079
650 0 _aPhysiology.
_972764
650 1 4 _aPlant Science.
_968085
650 2 4 _aComplementary and Alternative Medicine.
_970736
650 2 4 _aPharmacology.
_967844
650 2 4 _aMedicinal Chemistry.
650 2 4 _aAgriculture.
_968079
650 2 4 _aPhysiology.
_972764
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031636806
776 0 8 _iPrinted edition:
_z9783031636820
776 0 8 _iPrinted edition:
_z9783031636837
856 4 0 _uhttps://doi.org/10.1007/978-3-031-63681-3
912 _aZDB-2-SBL
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