| 000 | 04738nam a22006255i 4500 | ||
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| 001 | 978-3-031-63118-4 | ||
| 003 | DE-He213 | ||
| 005 | 20251030113247.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 241027s2024 sz | s |||| 0|eng d | ||
| 020 |
_a9783031631184 _9978-3-031-63118-4 |
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| 024 | 7 |
_a10.1007/978-3-031-63118-4 _2doi |
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_aMJCM _2bicssc |
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_aMED044000 _2bisacsh |
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| 245 | 1 | 0 |
_aHuman Challenge Studies for Vaccine Development _h[electronic resource] / _cedited by Fabio Bagnoli, Giuseppe Del Giudice, Sanjay K. Phogat, Rino Rappuoli. |
| 250 | _a1st ed. 2024. | ||
| 264 | 1 |
_aCham : _bSpringer Nature Switzerland : _bImprint: Springer, _c2024. |
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| 300 |
_aVIII, 377 p. 40 illus., 25 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aCurrent Topics in Microbiology and Immunology, _x2196-9965 ; _v445 |
|
| 505 | 0 | _aA brief history of human challenge studies (1900-2021) emphasising the virology, regulatory and ethical requirements, raison d’etre, ethnography, selection of volunteers and unit design -- Regulatory aspects of human challenge studies.-Controlled Human Infection challenge studies with RSV -- Human challenge studies with coronaviruses old and new -- Experimental urethral infection with Neisseria gonorrhoeae -- Helicobacter pylori.-Controlled human infection with Bordetella pertussis Human challenge studies for cholera -- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli -- Challenges in developing a controlled human tuberculosis challenge model -- Shigella Controlled Human Infection Models: Current and Future Perspectives -- The background, role and outline approach for development of a Controlled Human Infection Model for Nontyphoidal Salmonella -- Controlled Human Malaria Infection studies in Africa - past, present, and future -- Controlled infection of humans with the hookworm parasite Necator americanus to accelerate vaccine development. | |
| 520 | _aThis volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest. These studies can broaden our knowledge on infections that have a rather low natural infection rate, but still bear a great threat to global health. The authors also present instances, where no suitable animal model is available to help understand human immune responses to a specific pathogen. The recent SARS-CoV-2 pandemic is another example, where studies that are directly conducted in humans, could save valuable time. Human challenge studies can provide immunogenicity and early efficacy data for vaccine development. However, similar models could be used for studying a wide variety of medical treatments such as monoclonal antibodies, antibiotics, antivirals and bacteriophages. The chapters in this volume cover several pathogens, including viruses, bacteria and parasites, scientific and technical aspects as well as descriptions of regulatory, ethical and manufacturing requirements. The book serves as a valuable resource for scientists and clinicians working on human pathogens. | ||
| 650 | 0 |
_aImmunology. _969214 |
|
| 650 | 0 |
_aMedical microbiology. _963858 |
|
| 650 | 0 |
_aMedicine _xResearch. _962598 |
|
| 650 | 0 |
_aBiology _xResearch. _965629 |
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| 650 | 0 |
_aDiseases _xCauses and theories of causation. _978871 |
|
| 650 | 1 | 4 |
_aImmunology. _969214 |
| 650 | 2 | 4 |
_aMedical Microbiology. _963858 |
| 650 | 2 | 4 |
_aTranslational Research. _970704 |
| 650 | 2 | 4 |
_aPathogenesis. _978872 |
| 700 | 1 |
_aBagnoli, Fabio. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt _986682 |
|
| 700 | 1 |
_aDel Giudice, Giuseppe. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt _986683 |
|
| 700 | 1 |
_aPhogat, Sanjay K. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt _986684 |
|
| 700 | 1 |
_aRappuoli, Rino. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt _986685 |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer Nature eBook | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783031631177 |
| 776 | 0 | 8 |
_iPrinted edition: _z9783031631191 |
| 776 | 0 | 8 |
_iPrinted edition: _z9783031631207 |
| 830 | 0 |
_aCurrent Topics in Microbiology and Immunology, _x2196-9965 ; _v445 _986686 |
|
| 856 | 4 | 0 | _uhttps://doi.org/10.1007/978-3-031-63118-4 |
| 912 | _aZDB-2-SBL | ||
| 912 | _aZDB-2-SXB | ||
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