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020 _a9783031685507
_9978-3-031-68550-7
024 7 _a10.1007/978-3-031-68550-7
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aSCI089000
_2bisacsh
072 7 _aPSAN
_2thema
245 1 0 _aTranscriptional Regulation by Neuronal Activity
_h[electronic resource] :
_bTo the Nucleus and Back /
_cedited by Ramendra N. Saha, Serena M. Dudek.
250 _a2nd ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aXI, 595 p. 73 illus., 68 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
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505 0 _aSection 1: Activity-regulated Transcription: Getting to the Nucleus -- Fos/AP-1 as an exemplar for the study of neuronal activity-dependent gene regulation -- Calcium signaling to the nucleus -- Protein transport from synapse-to-nucleus and the regulation of gene expression -- Gene regulation by nuclear calcium and its antagonism by NMDAR/TRPM4 signaling -- Chemoelectric signaling, protein translocation and neuronal transcription -- Section 2: Activity-regulated Transcription: Epigenetic Regulation -- Histone variants in neuronal transcription and behavioral regulation -- Genome and epigenome engineering approaches to studying neuronal activity-dependent transcriptional enhancers -- Higher-order genome organization in the control of neuronal identity and neural circuit plasticity -- Chromatin remodelers in neuronal gene transcription -- Section 3: Activity-regulated Transcription: Role in Nervous System Function -- Nature and nurture converge in the nucleus to regulate activity-dependent neuronal development -- Roles for the MEF2 transcription factors in synapse and circuit development and plasticity -- Activity-related transcription: role in addiction -- Epigenetic priming of activity-dependent transcription in drug addiction -- Molecular intersection of activity-dependent gene expression and behavior: the transcriptomic signature of long-term memory consolidation -- Perturbations to stimulus-dependent gene activity patterns in neurodegenerative disorders -- Section 4: New Tools to Study and Use Activity-regulated Transcription -- Genome editing technologies for investigation of activity dependent transcription -- Imaging activity dependent gene expression in neurons: RNA tagging technologies -- Optogenetic approaches to study IEG activation -- New Genome-wide Technologies to Study Activity-regulated Transcription.
520 _aThis book discusses the regulation of gene transcription by neuronal activity that is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back, 2nd edition illustrates how signals are transmitted to the nucleus in response to neuronal activity, which genes are regulated and how this is achieved, and how these changes in gene expression alter neuronal function. The aim of this second edition is to highlight key advances in the field since the first edition. The book is divided into four sections. The first highlights how signals get to the nucleus from the membrane in response to synaptic or neuronal activity. Included are chapters on the pathways that transmit signals from synapses to nuclei. The second section focuses on epigenetic regulatory processes of activity-induced gene transcription, an area that has exploded in the past few years. The third section navigates the role of activity-induced genes in physiological processes such as learning and memory, and human developmental disorders such as those associated with the autism spectrum. The fourth section highlights groundbreaking technological advances in the field, which have allowed activity-regulated transcription to be used as a tool to study learning and memory.
650 0 _aNeurosciences.
_968384
650 0 _aNeurology .
_966816
650 0 _aGenetics.
_968863
650 1 4 _aNeuroscience.
_968386
650 2 4 _aNeurology.
_966816
650 2 4 _aGenetics.
_968863
700 1 _aSaha, Ramendra N.
_eeditor.
_0(orcid)0000-0002-5494-2584
_1https://orcid.org/0000-0002-5494-2584
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
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700 1 _aDudek, Serena M.
_eeditor.
_0(orcid)0000-0003-4094-8368
_1https://orcid.org/0000-0003-4094-8368
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_987407
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031685491
776 0 8 _iPrinted edition:
_z9783031685514
776 0 8 _iPrinted edition:
_z9783031685521
856 4 0 _uhttps://doi.org/10.1007/978-3-031-68550-7
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