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020 _a9783031666865
_9978-3-031-66686-5
024 7 _a10.1007/978-3-031-66686-5
_2doi
050 4 _aRC268.4-.44
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072 7 _aSCI029000
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245 1 0 _aEpigenetic Mechanisms in Breast Cancer Therapy and Resistance
_h[electronic resource] /
_cedited by Sanchita Bhatnagar.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aV, 106 p. 24 illus., 23 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x2214-8019 ;
_v1465
505 0 _aChapter 1 - MDIG in breast cancer progression and metastasis -- Chapter 2 - Tumor Microenvironment and Epigenetic Implications in Breast Cancer Progression -- Chapter 3 - The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity -- Chapter 4 - Epigenetic Modulations by Microbiome in Breast Cancer -- Chapter 5 - Facilitates chromatin transcription in breast and other cancers -- Chapter 6 - Advances in epigenetic therapeutics for breast cancer -- Chapter 7 - Detection methods for epigenetic mechanisms in breast cancer.
520 _aEpigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are a hallmark of tumorigenesis and metastasis. Conventionally, cancer was thought to be a genetic disease, but recent advancement in the field identified an abundance of epigenetic abnormalities along with genetic alterations. The extensive reprogramming of epigenetic machinery in cancer includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. Additionally, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, and recent FDA approval of epigenetic drugs for cancer treatment. This book focuses on the epigenetic mechanisms in breast cancertherapy and resistance. It is organized into three sections, including epigenetic mechanisms in breast cancer, targeting epigenetic mechanisms for new therapies, and new and emerging methodologies to study epigenetic alterations in breast cancer. Chapters highlight various epigenetic regulations that prevent breast cancer growth and progression, as well as epigenetic alterations that contribute to breast cancer progression. This text is a useful methodology book for researchers and students interested in epigenetics in breast cancer and the fundamentals of cancer biology.
650 0 _aCancer
_xGenetic aspects.
_973501
650 0 _aEpigenetics.
_977287
650 0 _aCancer
_xTreatment.
_963722
650 0 _aMedical microbiology.
_963858
650 1 4 _aCancer Genetics and Genomics.
_973502
650 2 4 _aEpigenetics.
_977287
650 2 4 _aCancer Therapy.
_973414
650 2 4 _aMedical Microbiology.
_963858
700 1 _aBhatnagar, Sanchita.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_987995
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031666858
776 0 8 _iPrinted edition:
_z9783031666872
776 0 8 _iPrinted edition:
_z9783031666889
830 0 _aAdvances in Experimental Medicine and Biology,
_x2214-8019 ;
_v1465
_967831
856 4 0 _uhttps://doi.org/10.1007/978-3-031-66686-5
912 _aZDB-2-SBL
912 _aZDB-2-SXB
999 _c65184
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