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020 _a9789819779055
_9978-981-97-7905-5
024 7 _a10.1007/978-981-97-7905-5
_2doi
050 4 _aQH671
072 7 _aPSF
_2bicssc
072 7 _aSCI017000
_2bisacsh
072 7 _aPSF
_2thema
245 1 0 _aApoptosis and Human Health: Understanding Mechanistic and Therapeutic Potential
_h[electronic resource] /
_cedited by Kuladip Jana.
250 _a1st ed. 2024.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2024.
300 _aXX, 457 p. 78 illus., 74 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aChapter 1: Apoptosis: Intricate connections in cell death pathways and disease implications -- Chapter 2: Apoptosis: A Controlled Cell’s Fate -- Chapter 3: Apoptosis: Novel insights into the role of death receptors and caspases in cell fate -- Chapter 4: Apoptosis: Mechanisms and Clinical Implications -- Chapter 5: Apoptosis and Mitochondria: Cell death mechanisms -- Chapter 6: Apoptosis: ER stress and Disease pathology -- Chapter 7: Apoptosis: Oxidative stress and Antioxidants -- Chapter 8: Caspase Independent Apoptosis: New Insights and Current Perspectives -- Chapter 9: Role of Apoptosis in Cancer: Therapeutic targets and strategies -- Chapter 10: Mechanisms of PANoptosis and its implications in cancer progression and treatment -- Chapter 11: Role of Apoptosis in Neurodegeneration: Therapeutic targets and strategies.-b Chapter 12: Role of Apoptosis in Diabetes: Therapeutic targets and strategies -- Chapter 13: Role of Apoptosis in Cardiovascular diseases: Therapeutic targets and strategies -- Chapter 14: Chapter 15: Role of Apoptosis in Parasitic infections: Therapeutic targets and strategies -- Chapter 15: Role of Apoptosis in Viral infections with special reference to Covid 19: Therapeutic targets and strategies -- Chapter 16: Role of Apoptosis in male Infertility: Therapeutic targets and strategies -- Chapter 17: Role of Apoptosis in aging: Therapeutic targets and strategies -- Chapter 18: Apoptosis: Natural product-derived small molecules as Therapeutics -- Chapter 19: Apoptosis-based therapeutics and inhibitors in clinical trials or in preclinical state -- Chapter 20: Apoptosis and cancer immunotherapy: Current mechanisms and emerging strategies.
520 _aThis book comprehensively reviews the recent advancements in apoptosis research and evaluates its therapeutic targets and strategies in controlling various human diseases. The initial chapter presents the molecular components that regulate apoptosis and its importance for pathogenic processes. The subsequent chapters discuss the molecular mechanisms and signaling pathways involved in apoptosis induction and inhibition. The book also examines the role of mitochondria-driven apoptosis and therapeutic strategies for targeting mitochondria-mediated cell death. Further, the book discusses the role of apoptosis in different diseases, including neurodegeneration, cancer, diabetes, cardiovascular diseases, parasitic infections, autoimmune diseases, reproductive disorders, and infertility. Towards the end, the book outlines the recent advances in the field of apoptosis-based therapies and explores some highlights of a very active field of drug development. This book is useful for the researchers involved in designing and developing new drugs and drug targets for the treatment of different human diseases.
650 0 _aCell death.
650 0 _aDiseases.
_968840
650 0 _aCytology.
_967436
650 1 4 _aCell Death.
650 2 4 _aDiseases.
_968840
650 2 4 _aCell Biology.
_967440
700 1 _aJana, Kuladip.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_989285
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789819779048
776 0 8 _iPrinted edition:
_z9789819779062
776 0 8 _iPrinted edition:
_z9789819779079
856 4 0 _uhttps://doi.org/10.1007/978-981-97-7905-5
912 _aZDB-2-SME
912 _aZDB-2-SXM
999 _c65901
_d65901