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020 _a9783031763823
_9978-3-031-76382-3
024 7 _a10.1007/978-3-031-76382-3
_2doi
050 4 _aRD592.5-596
072 7 _aMNN
_2bicssc
072 7 _aMED085010
_2bisacsh
072 7 _aMNN
_2thema
245 1 0 _aPeripheral Nerve Sheath Tumors
_h[electronic resource] :
_bFrom Preclinical Studies to Advanced Therapies /
_cedited by Ignazio Gaspare Vetrano, Vittoria Nazzi.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aX, 217 p. 120 illus., 80 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aOverview on sporadic and NF-related tumors -- Natural history and clinical evolution of PNST in neurofibromatosi -- Advancement in genetic and molecular landscapes -- Multi-omic analyses for biomarker discovery and characterization of PNST -- Preclinical NF1-PNST models and potential drug resistance mechanism -- MRI in the diagnosis of PNST: state-of-the-art and recent advancements -- Developing the role of molecular imaging PET in PNST -- A clinical summary of PNST in adults -- Clinical assessment of tumor predisposition syndromes - related nerve sheath tumors in children -- IOUS and CEUS in PNS tumor -- Neurophysiological evaluation and intraoperative neurophysiology monitoring in peripheral nervous system tumor -- Surgical management of peripheral nerve sheath tumors -- Surgical Management of Pediatric PNS -- Fluorescent-guided surgery of PNST -- Esoscope in PNS tumors surgery -- Preserving nerve function and reconstruction in MPNS tumors -- New oral chemotherapy and MEK inhibitor (and other treatments for benign PNST) -- Systemic treatment in malignant peripheral nerve sheath tumors: current practice and future possibilities -- Proton and carbon ion therapy for MPNST -- Radiomics and machine learning in PNST.
520 _aThis book offers an update about peripheral nerve sheath tumors (PNST), both in their benign and malignant forms (MPNST). Starting from the most innovative preclinical studies about genetic and omics characterization, it then explores the traditional and advanced imaging modalities (ultrasound, DTI, etc) and the electrophysiological assessment. Another relevant part is reserved to the description of the most recent surgical techniques (fluorescent dye for intraoperative surgical guidance, neurophysiological monitoring, esoscopic view). Finally, new oral treatment for PNST related to neurocutaneous diseases (as selumetinib in plexiform neurofibromas) is described. Written by worldwide experts in each specifical field, if offers a multidisciplinary vision to PNST, approaching the topic in a translational way, from preclinical studies to the current medical practice. The ideal readers are all health operators involved in the treatment of these tumors- from neurosurgeons to radiologists, neurologists, geneticists, biologists, etc) as well as medical students in these disciplines.
650 0 _aNervous system
_xSurgery.
_974689
650 0 _aRadiology.
650 0 _aNeurology .
_966816
650 0 _aGenetics.
_968863
650 1 4 _aNeurosurgery.
_974691
650 2 4 _aRadiology.
650 2 4 _aNeurology.
_966816
650 2 4 _aGenetics and Genomics.
_968866
700 1 _aVetrano, Ignazio Gaspare.
_eeditor.
_0(orcid)0000-0003-0664-9700
_1https://orcid.org/0000-0003-0664-9700
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_990010
700 1 _aNazzi, Vittoria.
_eeditor.
_0(orcid)0000-0003-1835-6382
_1https://orcid.org/0000-0003-1835-6382
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_990011
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031763816
776 0 8 _iPrinted edition:
_z9783031763830
776 0 8 _iPrinted edition:
_z9783031763847
856 4 0 _uhttps://doi.org/10.1007/978-3-031-76382-3
912 _aZDB-2-SME
912 _aZDB-2-SXM
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