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020 _a9783031810251
_9978-3-031-81025-1
024 7 _a10.1007/978-3-031-81025-1
_2doi
050 4 _aRS400-431
072 7 _aPNN
_2bicssc
072 7 _aPSB
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072 7 _aSCI013020
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245 1 0 _aBiotherapeutics
_h[electronic resource] :
_bFrom small to large molecules and cells /
_cedited by Victoria Calzada, Hugo Cerecetto, Juan Pablo Tosar.
250 _a1st ed. 2024.
264 1 _aCham :
_bSpringer Nature Switzerland :
_bImprint: Springer,
_c2024.
300 _aVIII, 355 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
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490 1 _aTopics in Medicinal Chemistry,
_x1862-247X ;
_v42
505 0 _aSection 1 Basic concepts and definitions -- Medicinal chemistry and biotherapeutics Overview and definitions -- Biotherapeutics General introduction.
520 _aThis book reviews biotherapeutics from a medicinal chemistry perspective. It covers proteins, nucleic acids, low molecular weight hormones, small peptides, extracellular vesicles, gene therapy, cell-based products, and tissue-engineered products. Expert contributors provide insights into the mechanisms of action and translational processes of biotherapeutics. Particular attention is given to the latest developments in therapeutic proteins and nucleic acids. Biotherapeutic formulation developments like encapsulation, structural modifications and nanovehiculization are also presented in this book. Divided into 15 chapters, the book begins with basic concepts and definitions of biotherapeutics from a medicinal chemistry standpoint. The following chapters focus on therapeutic proteins, monoclonal antibodies, protein production, and structural modifications. Other chapters cover topics such as antisense oligonucleotides, aptamers, mRNA, gene therapy, as well as other biotherapeutics like low molecular weight hormones and small peptides. The book concludes with an overview of biotherapeutic formulations and an authoritative discussion on regulatory aspects. Throughout the book, readers will learn how biotherapeutics, whether obtained through bioprocesses or not, impact bioresponses and can be utilized for therapeutic purposes. Given its breadth, the book appeals to researchers in medicinal chemistry and biotherapeutics, scholars of medicinal chemistry, students at all levels of biochemical studies, practitioners in the medical field, and anyone interested in biotherapeutics.
650 0 _aMedicinal chemistry.
650 0 _aTherapeutics.
_970087
650 0 _aProteins.
_970651
650 0 _aClinical biochemistry.
_967825
650 0 _aMedicine
_xResearch.
_962598
650 0 _aBiology
_xResearch.
_965629
650 0 _aBiomedical engineering.
650 1 4 _aMedicinal Chemistry.
650 2 4 _aTherapeutics.
_970087
650 2 4 _aProteins.
_970651
650 2 4 _aMedical Biochemistry.
_967828
650 2 4 _aBiomedical Research.
_965633
650 2 4 _aBiomedical Engineering and Bioengineering.
700 1 _aCalzada, Victoria.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_991005
700 1 _aCerecetto, Hugo.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_991006
700 1 _aTosar, Juan Pablo.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_991007
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031810244
776 0 8 _iPrinted edition:
_z9783031810268
776 0 8 _iPrinted edition:
_z9783031810275
830 0 _aTopics in Medicinal Chemistry,
_x1862-247X ;
_v42
_991008
856 4 0 _uhttps://doi.org/10.1007/978-3-031-81025-1
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912 _aZDB-2-SXC
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