| 000 | 03061nam a22003854u 4500 | ||
|---|---|---|---|
| 001 | 10.1002/9781394207145 | ||
| 003 | Wiley | ||
| 005 | 20251030120309.0 | ||
| 007 | cr nn 008mam|a | ||
| 008 | 230906t2023||||xxu fs| |0|| 0|eng|| | ||
| 020 |
_a9781394207145 _qelectronic |
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| 024 | 7 |
_a10.1002/9781394207145 _2doi |
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| 041 | _aeng | ||
| 100 | 1 |
_aCorey, E.J. _4aut _991664 |
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| 245 | 1 | 0 |
_aMolecules Engineered Against Oncogenic Proteins and Cancer _h[electronic resource] _cE.J. Corey, Yong‐Jin Wu |
| 250 | _a1 | ||
| 260 |
_bWiley _c2023 |
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| 264 | 1 |
_bWiley _c2023 |
|
| 300 | _a400pp.; | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _2rdaft |
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| 347 | _bPDF | ||
| 520 | _aMolecules Engineered Against Oncogenic Proteins and Cancer A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine's most challenging areas-cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented. With a very well-known chemist as an author, Molecules Engineered Against Oncogenic Proteins and Cancer includes information on: Each molecule's structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field Combining the most significant recent discoveries in a unique and useful way, Molecules Engineered Against Oncogenic Proteins and Cancer is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery. | ||
| 650 | 4 |
_aPharmaceutical & Medicinal Chemistry _991083 |
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| 650 | 4 |
_aOrganic Chemistry _965327 |
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| 650 | 4 |
_aPharmacology & Pharmaceutical Medicine _991316 |
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| 700 | 1 |
_aWu, Yong‐Jin _4aut _991665 |
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| 776 | 0 | 8 |
_iPrinted edition: _z9781394207084 |
| 856 | 4 | 0 |
_uhttps://doi.org/10.1002/9781394207145 _aWiley Online Library |
| 856 | 4 | 0 |
_uhttps://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9781394207145 _aWiley Online Library |
| 856 | 4 | 2 |
_3Cover Image _uhttps://onlinelibrary.wiley.com/cms/asset/3a9e77ae-6f36-484a-a00e-1d411a636079/9781394207145.cover.gif _aWiley Online Library |
| 999 |
_c67030 _d67030 |
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