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001			10.1002/9783527840458
003			Wiley
005			20251030120311.0
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008			240705t2024||||xxu fs| |0|| 0|eng||
020			_a9783527840458 _qelectronic
024	7		_a10.1002/9783527840458 _2doi
041			_aeng
245	0	0	_aRNA as a Drug Target _bThe Next Frontier for Medicinal Chemistry _h[electronic resource] _cEdited by John Schneekloth, Martin Pettersson, Raimund Mannhold, Helmut Buschmann, Jörg Holenz.
250			_a1
260			_bWiley _c2024
264		1	_bWiley _c2024
300			_a416pp.;
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _2rdaft
347			_bPDF
490	1		_aMethods and Principles in Medicinal Chemistry
520			_aDiscover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugs Existing paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process. RNA as a Drug Target: The Next Frontier for Medicinal Chemistry offers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals. RNA as a Drug Target readers will also find: A complete "toolbox" for working with RNA, from structure determination to screening and lead generation techniques A wide range of addressable targets and mechanisms, including splicing modulation, riboswitches, targeted degradation, and more Authoritative discussion of the potential of RNA-targeted small molecule therapeutics for drugging the epitranscriptome RNA as a Drug Target provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry.
650		4	_aDrug Discovery & Development _991621
650		4	_aBiochemistry _965465
650		4	_aBiomolecules (DNA, RNA, Peptides, etc.) _991323
653	0	0	_aProteins; regulatory RNA; drug developer; undruggable disease; ribonucleic acid; enzyme; receptor; drug target; new therapeutics; medical chemist; biochemist; molecular biologist; pharmaceutical industry
700	1		_aSchneekloth, John _4edt _991773
700	1		_aPettersson, Martin _4edt _991774
700	1		_aMannhold, Raimund _4edt _991775
700	1		_aBuschmann, Helmut _4edt _991776
700	1		_aHolenz, Jörg _4edt _991777
776	0	8	_iPrinted edition: _z9783527351008
830		0	_aMethods and Principles in Medicinal Chemistry _991626
856	4	0	_uhttps://doi.org/10.1002/9783527840458 _aWiley Online Library
856	4	0	_uhttps://onlinelibrary.wiley.com/action/showBook?doi=10.1002%2F9783527840458 _aWiley Online Library
856	4	2	_3Cover Image _uhttps://onlinelibrary.wiley.com/cms/asset/d9f541f8-0390-4132-86af-33a205ae917d/9783527840458.cover.gif _aWiley Online Library
999			_c67083 _d67083