| 000 | 03603cam a2200565Ki 4500 | ||
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| 001 | 9781315165646 | ||
| 003 | FlBoTFG | ||
| 005 | 20251030122307.0 | ||
| 006 | m o d | ||
| 007 | cr cnu|||unuuu | ||
| 008 | 211007s2022 xx o 000 0 eng d | ||
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_a9781315165646 _q(electronic bk.) |
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_a1315165643 _q(electronic bk.) |
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| 020 |
_a9781351677714 _q(electronic bk. : Mobipocket) |
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| 020 |
_a1351677713 _q(electronic bk. : Mobipocket) |
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| 020 |
_a9781351677721 _q(electronic bk. : EPUB) |
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| 020 |
_a1351677721 _q(electronic bk. : EPUB) |
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| 020 | _z9781032203300 | ||
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_a9781351677738 _q(electronic bk. : PDF) |
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| 020 |
_a135167773X _q(electronic bk. : PDF) |
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| 020 | _z9781138055902 | ||
| 035 | _a(OCoLC)1273727421 | ||
| 035 | _a(OCoLC-P)1273727421 | ||
| 050 | 4 | _aQP93.5 | |
| 072 | 7 |
_aMED _x008000 _2bisacsh |
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_aMED _x071000 _2bisacsh |
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_aSCI _x049000 _2bisacsh |
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| 072 | 7 |
_aPSD _2bicssc |
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| 100 | 1 |
_aLundblad, Roger L. _uLundblad Biotechnology, Chapel Hill, North Carolina, USA. _996146 |
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| 245 | 1 | 4 | _aThe Chemical Biology of Thrombin. |
| 250 | _aFirst edition. | ||
| 264 | 1 |
_a[Place of publication not identified] : _bCRC Press, _c2022. |
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| 300 | _a1 online resource (300 pages). | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 505 | 0 | _aChapter 1The History of ThrombinChapter 2The Formation of ThrombinChapter 3Structural Biology of ThrombinChapter 4The use of Protein Engineering (Mutagenesis) to Study Functional Regions in ThrombinExpression and Characterization of Recombinant ThrombinsChapter 5Chemical Modification of ThrombinChapter 6The Interaction of Thrombin with Fibrinogen and FibrinChapter 7Thrombin and PlateletsChapter 8Inhibitors of Thrombin | |
| 520 | _aThis book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis. Key Features Reviews the history of Thrombin (Fibrin Ferment) Documents the relation of protein engineering and chemical modification in the study of thrombin Summarizes the interaction of thrombin with fibrinogen and fibrin Outlines the role of exosites in thrombin function Describes the development of an oral inhibitor for thrombin | ||
| 588 | _aOCLC-licensed vendor bibliographic record. | ||
| 650 | 0 |
_aThrombin. _996147 |
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| 650 | 7 |
_aMEDICAL / Biochemistry _2bisacsh _967828 |
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| 650 | 7 |
_aMEDICAL / Pharmacology _2bisacsh _964250 |
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| 650 | 7 |
_aSCIENCE / Life Sciences / Biology / Molecular Biology _2bisacsh _964014 |
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| 856 | 4 | 0 |
_3Taylor & Francis _uhttps://www.taylorfrancis.com/books/9781315165646 |
| 856 | 4 | 2 |
_3OCLC metadata license agreement _uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf |
| 942 | _cE-Books | ||
| 999 |
_c68283 _d68283 |
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