000 07835nam a2200829 i 4500
001 9780750340038
003 IOP
005 20251030124213.0
006 m eo d
007 cr cn |||m|||a
008 231201s2023 enka fob 000 0 eng d
020 _a9780750340038
_qebook
020 _a9780750340021
_qmobi
020 _z9780750340014
_qprint
020 _z9780750340045
_qmyPrint
024 7 _a10.1088/978-0-7503-4003-8
_2doi
035 _a(CaBNVSL)thg00083689
035 _a(OCoLC)1412322821
040 _aCaBNVSL
_beng
_erda
_cCaBNVSL
_dCaBNVSL
050 4 _aRC262
_b.M547 2023eb vol. 4
060 4 _aQZ 203
_bM632p 2023eb vol. 4
072 7 _aPHVN
_2bicssc
072 7 _aSCI009000
_2bisacsh
100 1 _aMierke, Claudia Tanja,
_eauthor.
_996509
245 1 0 _aPhysics of cancer.
_nVolume 4,
_pMechanical characterization of cells /
_cClaudia Tanja Mierke.
246 3 0 _aMechanical characterization of cells.
250 _aSecond edition.
264 1 _aBristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) :
_bIOP Publishing,
_c[2023]
300 _a1 online resource (various pagings) :
_billustrations (some color).
336 _atext
_2rdacontent
337 _aelectronic
_2isbdmedia
338 _aonline resource
_2rdacarrier
490 1 _a[IOP release $release]
490 1 _aBiophysical Society-IOP series
490 1 _aIOP ebooks. [2023 collection]
500 _a"Version: 20231101"--Title page verso.
504 _aIncludes bibliographical references.
505 0 _a1. Mechanosensing and the mechanotransduction of cells -- 1.1. An introduction to mechanosensation and mechanotransduction in living cells -- 1.2. Molecular mechanosensory behavior -- 1.3. The role of focal adhesion proteins -- 1.4. Interplay between mechanosensors -- 1.5. The interplay between focal adhesion proteins and cell-matrix receptors -- 1.6. The interplay between focal adhesion proteins and cell-cell adherence junctions -- 1.7. Force detection and transduction at adherens junctions -- 1.8. The transfer of mechanical forces at the cadherin-catenin complex -- 1.9. The role of the cytoskeleton -- 1.10. The role of the nucleus in sensing mechanical cues -- 1.11. Restrained mechanosensing in cancer -- 1.12. The regulation of gene expression in mechanotransduction in cancer cells -- 1.13. Alterations of the extracellular matrix environment in cancerous diseases -- 1.14. Conclusions and future perspectives
505 8 _a2. Overview and discussion of biophysical techniques for the mechanical characterization of cell nuclei and cells -- 2.1. Introduction to biophysical techniques used for the mechanical characterization of the nuclei of living cells -- 2.2. Analysis of nuclear positioning in a living cell -- 2.3. Analysis of the nuclear mechanical characteristics -- 2.4. Components of the nuclear framework contribute to mechanosensing -- 2.5. Analyses of nuclear mechanics -- 2.6. Analysis of the cytoskeleton and cell cortex -- 2.7. A critical discussion of mechanical measurements of living cells -- 2.8. A discussion of the selection of a specific biophysical technique -- 2.9. Conclusions and future research
505 8 _a3. Overview and discussion of biophysical techniques for the mechanical characterization of plasma membranes -- 3.1. A concise introduction to plasma membrane models -- 3.2. Giant plasma membrane vesicles serve as a model for the plasma membrane -- 3.3. Biophysical analysis of the plasma membrane of cells -- 3.4. The principles of the dynamics of the plasma membrane -- 3.5. Models and theories of the plasma membrane -- 3.6. The heat theory of the plasma membrane -- 3.7. The phenomenon of bioelectricity -- 3.8. The main findings in cancer research related to the plasma membrane -- 3.9. The prominent role of the bioelectrical code -- 3.10. Are aging and cancer opposite or the same sides of the coin in terms of pathology? -- 3.11. Bioelectric signal transmission within the mechanical microenvironment -- 3.12. Deciphering the direction of the flow of communication : separating the mechanical microenvironment from the bioelectrical signaling -- 3.13. Conclusions and future research
505 8 _a4. A survey of biophysical techniques used for the mechanical characterization of cell spheroids, organoids, and tumoroids -- 4.1. An overview of multicellular culture models -- 4.2. Tissue explants -- 4.3. Cell cluster formation and cell aggregates -- 4.4. Cell spheroids -- 4.5. Organoids -- 4.6. The effect of organoid vascularization -- 4.7. Tumoroids -- 4.8. Mechanical measurements of cell clusters, spheroids, organoids, or tumoroids -- 4.9. The effects of cell sorting and invasion -- 4.10. A discussion of the advantages and disadvantages of cell aggregate mechanical analyses -- 4.11. Conclusions and future research.
520 3 _aThis is the fourth volume of the highly regarded Physics of Cancer (Second Edition) series, written with the aim of making very important topics in the physics of cancer visible to the research community. This fourth volume deals with mechanobiology using biophysical methods. The first chapter deals with mechanosensing and mechanotransduction on vastly different length scales. The second chapter discusses biophysical techniques for mechanical phenotype characterization of cells and nuclei. The third provides an overview of the mechanical phenotype of the plasma membrane. The fourth chapter contains the latest insights into the mechanical assessment of cell spheroids, organoids and tumoroids. The basic approach of this text is to present the latest promising findings to the scientific community, addressing scientists at all career stages. Part of Biophysical Society-IOP series.
521 _aScientists, researchers, graduate students, instructors in biophysics.
530 _aAlso available in print.
538 _aMode of access: World Wide Web.
538 _aSystem requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.
545 _aClaudia Tanja Mierke is Head of the Department of Biological Physics at the Peter Debye Institute for Soft Matter Physics at Leipzig University. Her primary research areas are cell biophysics and cell mechanics, adhesion, motility (invasion) in biomimetic matrices, cancer and inflammation, cancer metastasis and tumor microenvironment mechanics. She has published over 150 refereed journal articles, books and book chapters largely dealing with soft matter physics and the physics of cancer. Over the past 18 years, Claudia had taught courses in biophysics, soft matter physics, cell biology for physicists and cellular biophysics, to both undergraduate and graduate students.
588 0 _aTitle from PDF title page (viewed on December 1, 2023).
650 0 _aBiophysics.
_966239
650 0 _aPathology, Molecular.
_996510
650 0 _aCell physiology.
_996511
650 1 2 _aCell Transformation, Neoplastic.
_996512
650 2 2 _aCell Physiological Phenomena.
_996513
650 2 2 _aTumor Microenvironment.
_996514
650 2 2 _aBiomechanical Phenomena.
_996515
650 2 _aNeoplasms.
_963724
650 2 _aBiophysics.
_966239
650 2 _aPathology, Molecular.
_996510
650 7 _aBiophysics.
_2bicssc
_966239
650 7 _aSCIENCE / Life Sciences / Biophysics.
_2bisacsh
_995352
650 0 _aCancer cells
_xMechanical properties.
_996516
650 0 _aCancer.
_94311
710 2 _aInstitute of Physics (Great Britain),
_epublisher.
_917702
776 0 8 _iPrint version:
_z9780750340014
_z9780750340045
830 0 _aIOP (Series).
_pRelease 23.
830 0 _aBiophysical Society-IOP series.
_996362
830 0 _aIOP ebooks.
_p2023 collection.
856 4 0 _uhttps://iopscience.iop.org/book/mono/978-0-7503-4003-8
942 _cE-Books
999 _c68367
_d68367