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001 9780750353878
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020 _a9780750353878
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020 _a9780750353861
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020 _z9780750353854
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020 _z9780750353885
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024 7 _a10.1088/978-0-7503-5387-8
_2doi
035 _a(CaBNVSL)thg00083985
035 _a(OCoLC)1458668809
040 _aCaBNVSL
_beng
_erda
_cCaBNVSL
_dCaBNVSL
050 4 _aRS380
_b.B535 2024eb vol. 2
060 4 _aQV 778
_bB575i 2024eb vol. 3
072 7 _aTCB
_2bicssc
072 7 _aMED009000
_2bisacsh
100 1 _aAl-Harrasi, Ahmed,
_eauthor.
_996990
245 1 _aIntroduction to pharmaceutical biotechnology.
_nVolume 2,
_pEnzymes, proteins and bioinformatics /
_cAhmed Al-Harrasi, Saurabh Bhatia, Ajmal Khan.
246 3 _aEnzymes, proteins and bioinformatics.
250 _aSecond edition.
264 1 _aBristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) :
_bIOP Publishing,
_c[2024]
300 _a1 online resource (various pagings) :
_billustrations (some color).
336 _atext
_2rdacontent
337 _aelectronic
_2isbdmedia
338 _aonline resource
_2rdacarrier
490 1 _a[IOP release $release]
490 1 _aIOP ebooks. [2024 collection]
500 _a"Version: 20240901"--Title page verso.
504 _aIncludes bibliographical references.
505 8 _a3. Industrial enzymes and their applications -- 3.1. Industrial enzymes -- 3.2. Bacterial [alpha]-amylases -- 3.3. Fungal [alpha]-amylases -- 3.4. Bacterial proteases -- 3.5. Fungal proteases -- 3.6. Glucose isomerase (d-xylose ketol-isomerase; EC. 5.3.1.5) -- 3.7. Penicillinase -- 3.8. Chloramphenicol acetyltransferase -- 3.9. Aminoglycoside antibiotic inactivating enzymes -- 3.10. Fibrinolytic enzymes -- 3.11. Biotechnological applications of enzymes -- 3.12. Industrial enzymes -- 3.13. The role of enzymes in the synthesis of functional foods -- 3.14. Enzymes used as additives to food
505 8 _a4. Immobilization of enzymes -- 4.1. Introduction -- 4.2. Types of immobilization -- 4.3. Genetic engineering for microbial enzyme production -- 4.4. Protein studies for modification of commercial enzymes -- 4.5. Enzyme and cell immobilization -- 4.6. Immobilization methods -- 4.7. Choice of immobilization technique -- 4.8. Immobilization of cells -- 4.9. Manufacture of commercial products -- 4.10. Immobilized enzymes for biomedical applications -- 4.11. Detecting biomass with immobilized cells via bioluminescence and other biosensor uses -- 4.12. Bioluminescence-based microbial biosensors -- 4.13. Immobilization of microalgae
505 8 _a5. Biosensors -- 5.1. Introduction -- 5.2. Principles of a biosensor -- 5.3. Different types of biosensors -- 5.4. Applications of biosensors -- 5.5. Recent advancements in biosensor technology -- 5.6. Microbial biosensors utilizing synthetic biology and genetic/protein engineering techniques -- 5.7. Technological comparison of biosensors -- 5.8. Prospective challenges, and inherent limitations associated with biosensor technology -- 5.9. Grand challenges in biosensors and biomolecular electronics -- 5.10. The Implementation and commercialization of biosensing devices
505 8 _a6. Biotransformation and enzymes -- 6.1. Introduction -- 6.2. Types of biotransformation reactions -- 6.3. Sources of biocatalysts and techniques for biotransformation -- 6.4. Product recovery in biotransformations -- 6.5. Application of biotransformation in the production of pharmaceutical products -- 6.6. Mechanisms of enzyme action in biotransformation -- 6.7. Biotransformation in environmental applications -- 6.8. Emerging technologies in biotransformation -- 6.9. Biotransformation challenges and future perspectives
505 8 _a7. Introduction to genomics -- 7.1. Introduction -- 7.2. Characterizations in genomics -- 7.3. Historical background -- 7.4. Genome sequencing -- 7.5. Understanding bioinformatics and sequencing -- 7.6. Comparative genomics as a technique to understand evolution -- 7.7. Gene estimation and counting -- 7.8. Genomes : genome evolution -- 7.9. Algae bioinformatics -- 7.10. Functional genomics -- 7.11. Structural genomics -- 7.12. Epigenomics and epigenetics -- 7.13. Pharmacogenomics -- 7.14. Population genomics -- 7.15. Microbiome genomics -- 7.16. Synthetic biology and genome editing -- 7.17. Systems biology and genomics -- 7.18. Genome-wide association studies (GWAS) -- 7.19. Future of genomics
505 8 _a8. Basics of proteomics -- 8.1. Introduction -- 8.2. Types of proteomics -- 8.3. Basic techniques involved in proteomics -- 8.4. Complete proteome of Mycoplasma genitalium -- 8.5. Architecture and design of the nuclear pore complex -- 8.6. Functional genomics and systems biology -- 8.7. Synthetic genomics -- 8.8. Advanced techniques in proteomics -- 8.9. Proteogenomics -- 8.10. Single-cell proteomics -- 8.11. Clinical and diagnostic proteomics -- 8.12. Metaproteomics -- 8.13. Emerging topics in proteomics -- 8.14. Ethical and data management issues in proteomics -- 8.15. Cellular and molecular dynamics -- 8.16. Membrane proteomics -- 8.17. Subcellular proteomics
505 8 _a9. Bioinformatics -- 9.1. Introduction -- 9.2. History of bioinformatics -- 9.3. Sequences and nomenclature -- 9.4. Investigation by means of bioinformatics tools -- 9.5. Computational approaches in bioinformatics -- 9.6. Bioinformatics in precision medicine -- 9.7. Translational bioinformatics -- 9.8. Bioinformatics in drug discovery and development -- 9.9. CRISPR and genome editing in bioinformatics -- 9.10. Integrative and multi-omics analysis
505 8 _a10. Protein and enzyme engineering -- 10.1. Protein and enzyme engineering -- 10.2. Designing macromolecules -- 10.3. Protein engineering versus enzyme engineering -- 10.4. Protein engineering -- 10.5. Foundation of protein (enzyme) engineering -- 10.6. Basic assumptions for protein engineering -- 10.7. Steps involved in protein engineering -- 10.8. Methods of protein engineering -- 10.9. Mutagenesis and selection of mutant enzymes -- 10.10. Gene modifications or gene synthesis for protein engineering -- 10.11. Multi-enzyme systems -- 10.12. Chemical modification of enzyme -- 10.13. Some early achievements of protein engineering -- 10.14. Computational approaches in protein engineering -- 10.15. Directed evolution techniques -- 10.16. Post-translational modifications -- 10.17. Structural flexibility and allosteric regulation -- 10.18. Protein-protein and protein-ligand interactions -- 10.19. Applications in synthetic biology -- 10.20. Engineering multi-functional proteins -- 10.21. Ethical and safety considerations -- 10.22. Studies in protein engineering -- 10.23. Single-molecule techniques in protein engineering -- 10.24. High throughput screening methods -- 10.25. Protein engineering for nanotechnology.
505 _a1. Introduction to enzymes and their applications -- 1.1. Introduction -- 1.2. Properties of enzymes -- 1.3. Catalysis -- 1.4. The structure of enzymes -- 1.5. Structural features : primary and secondary structures -- 1.6. Nomenclature and classification -- 1.7. The mechanism of action of enzymes -- 1.8. Catalysis via chymotrypsin -- 1.9. Enzyme inhibition -- 1.10. Pharmaceutical applications -- 1.11. Plants and algae enzyme systems -- 1.12. Enzyme safety -- 1.13. Enzyme structure determination -- 1.14. Enzyme engineering and design -- 1.15. Enzymes in medicine and healthcare -- 1.16. Enzymes in bioremediation -- 1.17. Enzymes in agriculture and crop production -- 1.18. Enzymes in waste management
505 8 _a2. Technologies and procedures involved in enzyme production -- 2.1. Introduction -- 2.2. Enzyme production technology -- 2.3. Procedures involved in enzyme production -- 2.4. Recombinant proteins from algae -- 2.5. Enzyme immobilization techniques -- 2.6. Enzyme engineering for enhanced stability and activity -- 2.7. Upstream process intensification -- 2.8. Enzyme production from extreme environments -- 2.9. Downstream process intensification
506 _aFull-text restricted to subscribers or individual document purchasers.
520 3 _aThis book offers a detailed examination of biotransformation and enzymes, focusing on their crucial roles in biology and biotechnology. It is intended for students, researchers, and professionals who are interested in understanding the biochemical processes by which organisms metabolize various compounds and how enzymes facilitate these processes. The book's primary aim is to provide a clear connection between theoretical concepts and their practical applications, showcasing biotransformation as an essential tool for developing sustainable solutions in pharmaceuticals, environmental management, and industrial practices. It comprehensively covers various biotransformation reactions, highlighting their importance in producing valuable products, detoxifying substances, and minimizing waste.
521 _aScientists, researchers and practitioners in pharmaceutical biotechnology, biotechnology and biopharmaceuticals.
530 _aAlso available in print.
538 _aMode of access: World Wide Web.
538 _aSystem requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.
545 _aAhmed Al-Harrasi is a professor of organic chemistry and the vice chancellor for graduate studies, research and external relations at the University of Nizwa. He obtained his BSc in Chemistry from SQU and his MSc and PhD in Organic Chemistry from Free University of Berlin as a DAAD-fellow. Then he received the Fulbright award in 2008 for postdoctoral research in Chemical Biology from Cornell University. He is a founder and chair of the Natural and Medical Sciences Research Center. He is a member of the Scientific Council of UNESCO. He was named on the list of top 2% Scientists for the last three years. He has authored over 800 scientific papers and more than 20 books and book chapters. He received the Order of Royal Commendation from His Majesty, The Sultan of Oman as an outstanding Omani individual for his remarkable contribution and active role in research. Saurabh Bhatia is an Associate Professor within the Natural and Medical Sciences Research Centre at the University of Nizwa, Oman. He has published 79 referred journal articles and written 94 book chapters. Dr. Bhatia has also authored 10 books and is the Associate Editor on four international journals. Ajmal Khan is currently working as an Associate Professor in Natural and Medical Sciences Research Centre at the University of Nizwa, Oman. Dr. Khan published more than 450 articles in international peer review journals with impact factor of more than 2000 and citation more than 9000. Besides this, he has published two US patents, and three books and 13 books chapters. Dr. Khan is Associate Editor for four journals and on the editorial board of three international journals.
588 _aTitle from PDF title page (viewed on October 3, 2024).
650 _aPharmaceutical biotechnology.
_965164
650 _aPharmaceutical technology.
650 _aBioengineering.
_965166
650 _aBiotechnology.
_965162
650 1 2 _aTechnology, Pharmaceutical.
650 2 2 _aBiotechnology.
_965162
650 7 _aBiotechnology.
_2bicssc
_965162
650 7 _aMEDICAL / Biotechnology.
_2bisacsh
_963891
700 1 _aBhatia, Saurabh,
_eauthor.
_996991
700 1 _aKhan, Ajmal
_c(Ph. D. in biochemistry),
_eauthor.
_996992
710 2 _aInstitute of Physics (Great Britain),
_epublisher.
_917702
776 8 _iPrint version:
_z9780750353854
_z9780750353885
830 0 _aIOP (Series).
_pRelease 24.
830 _aIOP ebooks.
_p2024 collection.
856 4 _uhttps://iopscience.iop.org/book/mono/978-0-7503-5387-8
942 _cE-Books
999 _c68479
_d68479