000			08625nam a2200913 i 4500
001			9780750362092
003			IOP
005			20251030124835.0
006			m eo d
007			cr cn |||m|||a
008			240801s2024 enka fob 000 0 eng d
020			_a9780750362092 _qebook
020			_a9780750362085 _qmobi
020			_z9780750362078 _qprint
020			_z9780750362108 _qmyPrint
024	7		_a10.1088/978-0-7503-6209-2 _2doi
035			_a(CaBNVSL)thg00083965
035			_a(OCoLC)1451139882
040			_aCaBNVSL _beng _erda _cCaBNVSL _dCaBNVSL
050		4	_aRC271.R3 _bJ667 2024eb
060		4	_aWN 250 _bJ76p 2024eb
072		7	_aMF _2bicssc
072		7	_aMED080000 _2bisacsh
100	1		_aJones, Bleddyn, _eauthor. _997216
240	1		_aPractical radiobiology for proton therapy planning
245	1		_aQuantitative radiobiology for proton therapy / _cBleddyn Jones ; with contribution from Joshua Moore.
264		1	_aBristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : _bIOP Publishing, _c[2024]
300			_a1 online resource (various pagings) : _billustrations (some color).
336			_atext _2rdacontent
337			_aelectronic _2isbdmedia
338			_aonline resource _2rdacarrier
490	1		_a[IOP release $release]
490	1		_aIPEM-IOP series in physics and engineering in medicine and biology
490	1		_aIOP ebooks. [2024 collection]
500			_aRevised edition of: Practical radiobiology for proton therapy planning.
500			_a"Version: 20240701"--Title page verso.
504			_aIncludes bibliographical references.
505			_a1. Particle physics for biological interactions -- 1.1. Physical beam parameters, essential dosimetry and reference (or control) radiation requirements for RBE studies -- 1.2. Physics interacting with biology
505	8		_a2. The essential radiobiology background -- 2.1. Introduction -- 2.2. Background and models -- 2.3. The [alpha]/[beta] ratio and its choice for modelling particle therapies -- 2.4. The design of experiments for RBE determination and other purposes
505	8		_a3. Medical and surgical considerations that influence radiation tolerances, including interpretation of clinical trials -- 3.1. Introduction -- 3.2. Surgery -- 3.3. Cytotoxic chemotherapies -- 3.4. Age and other medical conditions -- 3.5. Reductions in prescribed dose -- 3.6. Interpretation of the case histories and literature -- 3.7. Clinical trials -- 3.8. Ethical issues -- 3.9. Mixed end points -- 3.10. The importance of follow-up -- 3.11. Publication bias
505	8		_a4. Treatment planning and further medical perspectives -- 4.1. Introduction
505	8		_a5. Historical development of radiotherapy : what was learned from fast neutrons including their linkage with proton relative biological effect -- 5.1. Introduction -- 5.2. A brief synopsis -- 5.3. Neutron therapy -- 5.4. More recent developments based on neutron studies -- 5.5. Estimation of neutron RBE from neutron energy -- 5.6. Some important conclusions
505	8		_a6. Fractionation modelling -- 6.1. Introduction and background radiobiology -- 6.2. A brief history of fractionation -- 6.3. Modelling of fractionation -- 6.4. The use of the linear quadratic model with large fraction sizes -- 6.5. Optimisation of fractionation using calculus methods -- 6.6. Other contributions to fractionation -- 6.7. Summary
505	8		_a7. The scientific case for using a variable proton RBE rather than a constant RBE -- 7.1. Introduction -- 7.2. Discussion
505	8		_a8. A general RBE linear energy-efficiency model for protons and light ions -- 8.1. Introduction -- 8.2. The available experimental data and its important limitations -- 8.3. Description of the Z-specific model -- 8.4. The graphical results -- 8.5. Further investigations : properties of LETU -- 8.6. Conclusions and what remains to be done
505	8		_a9. Inclusion of the energy-efficiency LET and RBE model in proton therapy -- 9.1. Introduction -- 9.2. RBE uncertainties -- 9.3. Description of the quantitative model -- 9.4. RBE graphical examples -- 9.5. Some comparisons with experimental data sets -- 9.6. Two clinical examples where PBT could be sub-optimal -- 9.7. Prediction of tumour response from the RBE increment -- 9.8. Intensification of dose rates -- 9.9. Concluding discussion
505	8		_a10. Proton therapy risk assessment using small increments in RBE in the central nervous system and estimation of remission times -- 10.1. Introduction -- 10.2. Methods -- 10.3. Results -- 10.4. Discussion -- 10.5. Conclusions
505	8		_a11. Radiobiological interpretation of the finding of RBE changes within similar SOBPs placed at superficial and deep locations in passively scattered beams but not in scanned pencil beams -- 11.1. Introduction -- 11.2. Methods -- 11.3. Results -- 11.4. Discussion -- 11.5. Conclusions
505	8		_a12. Particle therapy dose-time compensations in unintended interruptions and re-treatments -- 12.1. Introduction -- 12.2. Unintended treatment interruptions -- 12.3. Re-treatments
505	8		_a13. Errors of Bragg peak positioning and their radio-biological correction -- 13.1. Introduction -- 13.2. Model description -- 13.3. Conclusions
505	8		_a14. What remains to be done : including FLASH dose rates and conclusions -- 14.1. Introduction -- 14.2. Dose escalation where circumstances permit -- 14.3. Simultaneous 'sensitisation' effects by new therapies -- 14.4. Sensitivity analysis of the energy-efficiency model -- 14.5. What could be achieved in a single international laboratory dedicated to high-LET radiobiology -- 14.6. Some untested situations -- 14.7. Conclusions.
506			_aFull-text restricted to subscribers or individual document purchasers.
520	3		_aThis book is an extension and major update of the author's previous work, titled Practical Radiobiology for Proton Therapy Planning (IOP Publishing 2018). The book describes the relative biological effectiveness (RBE) issues within proton therapy and advises on how to use a variable RBE within treatment planning and in dose prescription to improve the safety of proton and other forms on ion beam therapy. Decision-making advice is also provided for protocol breaches, retreatments, dose rate effects and risk assessment. This book is intended for those who already have basic knowledge of radiotherapy and radiobiology, although there is guidance through the fundamental principles for those who are 'discipline crossing'. Part of IPEM-IOP Series in Physics and Engineering in Medicine and Biology.
521			_aMedical engineering, biomedical engineers, clinicians specializing in proton therapy and radiotherapy and radiobiology. Proton therapy centers and large regional cancer centers.
530			_aAlso available in print.
538			_aMode of access: World Wide Web.
538			_aSystem requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.
545			_aBleddyn Jones, MD ScD FRCR, is an Emeritus Professor of Clinical Radiation Biology, University of Oxford. He has had over 40 years of interest and high impact research in neutron, proton and ion beam therapy and its associated radiobiology. He has made extensive contributions to the quantitative understanding of the relative biological effectiveness of particle therapy from the ballistic properties to their cellular and tissue effects. This includes many practical applications based on specific clinical situations, to guide proton therapy to safer and more effective outcomes.
588			_aTitle from PDF title page (viewed on August 1, 2024).
650			_aRadiobiology. _997217
650			_aRadiotherapy. _997218
650			_aProtons _xTherapeutic use. _997219
650	1	2	_aRadiobiology. _997217
650	1	2	_aRadiotherapy _xmethods. _996497
650	1	2	_aProton Therapy. _996929
650	2	2	_aRadiotherapy. _997218
650		7	_aPre-clinical medicine - basic sciences. _2bicssc _996521
650		7	_aMEDICAL / Radiology, Radiotherapy & Nuclear Medicine. _2bisacsh _996639
700	1		_aMoore, Joshua _c(Ph. D. in mathematics), _eauthor. _997220
710	2		_aInstitute of Physics (Great Britain), _epublisher. _917702
776		8	_iPrint version: _z9780750362078 _z9780750362108
830		0	_aIOP (Series). _pRelease 24.
830			_aIPEM-IOP series in physics and engineering in medicine and biology.
830			_aIOP ebooks. _p2024 collection.
856	4		_uhttps://iopscience.iop.org/book/mono/978-0-7503-6209-2
942			_cE-Books
999			_c68542 _d68542